Tumor specific delivery and radiation-enhanced tumor penetration of mesoporous silica nanoparticles for effective radionuclide therapy of ovarian peritoneal metastasis

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doi:10.1016/j.ijpharm.2024.125071

Tumor specific delivery and radiation-enhanced tumor penetration of mesoporous silica nanoparticles for effective radionuclide therapy of ovarian peritoneal metastasis

Derek Hargrove & Xiuling Lu et al. · 2024-12-09

Advanced ovarian cancer with peritoneal metastasis is challenging to treat. Limited tumor delivery and penetration of the therapeutics to deep tumor regions are significant barriers to effective treatment. The rising radiopharmaceuticals offer hopes for patients through targeted delivery. However, site specific delivery avoiding off target effect remain critical and challenging. We have developed radioactive

Links

DOI PubMed

Journal

International Journal of Pharmaceutics

Authors

Derek Hargrove, Sheyda Ranjbar, Mittal Darji, Sangho Nam, Robert J Dawson, Sumudu Katugampola, Xinhao Lin, Amy Brown, Natalia Carrasco-Rojas, Cameron Goodwin, Roger W. Howell, Wesley E. Bolch, Michael Jay, Andrew Salner, Xiuling Lu

Funding

MIRDcell Version 3 Nanoparticle-based Intraperitoneal Delivery of Combined Chemo-brachytherapy for Treatment of Ovarian Cancer Metastases Nanoparticle-based Intraperitoneal Delivery of Combined Chemo-radiotherapy for Treatment of Ovarian Cancer Metastases National Institutes of Health Grant RSG-15\u2013011-01-CDD Nanoparticle-based Intraperitoneal Delivery of Combined Chemo-radiotherapy for Treatment of Ovarian Cancer Metastases American Cancer Society Funding

NCI NIH HHS

R01 CA245139

NCI NIH HHS

R41 CA239989

NCI NIH HHS

R44 CA239989

National Institutes of Health National Cancer Institute

R44CA239989