Folate-chitosan nanoparticles loaded with an apolar acetogenin inhibiting the proliferation of cervical cancer cells
7Citations
The folk medicine Annona muricata is used widely against cancer. Three acetogenins AMPE I, AMPE II and AMPE III were isolated from the leaves of A. muricata and were identified as epomuricenin-A, epomuricenin-B and epomusenin-B respectively. FACS NPs were prepared and characterised by FTIR, particle size, zeta potential (ZP), TGA, SEM and TEM analysis. The average particle size and ZP of the encapsulated chitosan NPs and folic acid conjugated chitosan NP were 52 nm and 71 nm, 32.75 mV and 42.85 mV respectively. Among the acetogenins epomuricenin-A, AMPE I was more active in MTT assay as it portrays an IC