Systematic assessment of tumor necrosis at baseline in cervical cancer - An independent factor associated with poor outcome

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doi:10.1016/j.humpath.2023.12.003

Systematic assessment of tumor necrosis at baseline in cervical cancer - An independent factor associated with poor outcome

Olfa Chouchane-Mlik & Suzy M. Scholl et al. · 2023-12-20

Cervical cancer (CC) is a leading challenge in oncology worldwide, with high prevalence and mortality rates in young adults, most prominent in low to middle-income countries with marginal screening facilities. From the prospectively collected BioRAIDS (NCT02428842) cohort of primary squamous CC conducted in 7 European countries, a central pathology review was carried out on 294 patients' tumors. The focus was on identification of tumor-stromal characteristics such as CD8

Links

DOI PubMed

Journal

Human Pathology

TL;DR

Tumor necrosis can be assessed in the very first diagnostic biopsy and the data suggest that this rapid, simple and cost-effective biomarker, should be routinely assessed prior to treatment decisions.

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Authors

Olfa Chouchane-Mlik, Alexandra Oniga, Aurélien Latouche, Maral Halladjian, Felix B. Kleine-Borgmann, Jean-Jacques Gérardy, Michel Mittelbronn, Maud Kamal, Suzy M. Scholl