Effects of risk factors for ovarian cancer in women with and without endometriosis
To evaluate the associations between 10 well-established ovarian cancer risk factors and risk of ovarian cancer among women with vs. without endometriosis. Pooled analysis of 9 case-control studies in the Ovarian Cancer Association Consortium. Population-based. We included 8,500 women with ovarian cancer, 13,592 control women. Ten well-established ovarian cancer risk factors. Risk of ovarian cancer for women with and without endometriosis. Most risk factor-ovarian cancer associations were similar when comparing women with and without endometriosis, and no interactions were statistically significant. However, body mass index (BMI) 25-<30 kg/m The associations between ovarian cancer and most risk factors were similar among women with and without endometriosis. However, there was some suggestion of differences by endometriosis status for BMI, menopausal hormone therapy use, and genital talcum powder use, highlighting the complexity of ovarian cancer etiology.
Journal
Fertility and SterilityInstitutions
Authors
Funding
Epidemiology of Ovarian Cancer:New HypothesesHereditary Breast Cancer: Genetic and Molecular StudiesDNA POLYMORPHISMS IN OVARIAN CANCER--CASE CONTROL STUDYCASE CONTROL STUDY OF OVARIAN CANCER HORMONAL ETIOLOGYRISK FACTOR ANALYSIS OF BRCA1 AND BRCA2 CARRIERSDana-Farber/Harvard Cancer Center Ovarian Cancer SPOREOVARIAN CANCER RISK AND SURVIVAL IN BRCA CARRIERSPathologyCancer Research Training and Education CoordinationOvarian Cancer and Gonadotropin SignalingGenes, Hormones & Environment in an Ovarian Cancer ModelFollow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)Wellcome Trust FundingSteroid Hormone Genes and Ovarian Cancer RiskRegulatory T Cell Function in Ovarian CancerSURVEILLANCE EPIDEMIOLOGY & END RESULTS PROGRAMProject 1General Clinical Research CenterInflammation and Ovarian CancerWellcome Trust Grant 076113The Progesterone Receptor Gene and Ovarian Cancer RiskCollaborative Genetic Study of Ovarian Cancer RiskHormone Therapy and Risk of Ovarian CancerSURVEILLANCE EPIDEMIOLOGY AND END RESULTSDanish Cancer Society Grant 94 222 52Huntsman Cancer Institute FundingOvarian Cancer Australia FundingOvarian Cancer Research Alliance FundingClovis Oncology FundingUS Army Medical Research and Materiel Command Grant DAMD17-01-1-0729Medical Research and Materiel Command FundingRivkin Center for Ovarian Cancer FundingPfizer FundingAstraZeneca FundingCalifornia Cancer Research Program Grant 00-01389V-20170California Cancer Research Program Grant 2II0200National Science Foundation FundingNational Institutes of Health Grant DAMD17-02-1-0669SURVEILLANCE EPIDEMIOLOGY AND END RESULTSNational Institutes of Health Grant N01-CN55424National Institutes of Health Grant N01-PC67001National Institutes of Health Grant N01-PC67010NIH Grant P01-CA17054National Institutes of Health Grant P30-CA14089Dana-Farber/Harvard Cancer Center Ovarian Cancer SPOREHereditary Breast Cancer: Genetic and Molecular StudiesRISK FACTOR ANALYSIS OF BRCA1 AND BRCA2 CARRIERSCASE CONTROL STUDY OF OVARIAN CANCER HORMONAL ETIOLOGYDNA POLYMORPHISMS IN OVARIAN CANCER--CASE CONTROL STUDYSteroid Hormone Genes and Ovarian Cancer RiskNIH Grant R01-CA54419National Institutes of Health Grant R01-CA58598National Institutes of Health Grant R01-CA61132National Institutes of Health (NIH) Grant R01-CA87538The Progesterone Receptor Gene and Ovarian Cancer RiskOvarian Cancer and Gonadotropin SignalingU.S. Department of Defense (United States Department of Defense) Grant W81XWH-10-1-02802OVARIAN CANCER RISK AND SURVIVAL IN BRCA CARRIERSGeneral Clinical Research CenterPathologyNational Cancer Institute Grant P30-CA040214National Cancer Institute Grant R01-CA61107National Cancer Institute Grant R01-CA95023Follow-up of Ovarian Cancer Genetic Association and Interaction Studies (FOCI)National Center for Research Resources FundingLon V Smith Foundation Grant LVS-39420Cancer Council South Australia FundingCancer Council Victoria FundingCancer Council NSW FundingCancer Council Queensland FundingCancer Council Tasmania FundingPeter MacCallum Foundation FundingNational Health and Medical Research Council Grant 199600National Health and Medical Research Council Grant 400281National Health and Medical Research Council Grant 400413National Health and Medical Research Council Grant APP1173346