Assessment of lymph node metastases in patients with ovarian high-grade serous carcinoma: Incremental diagnostic value of dual-energy CT combined with morphologic parameters
To explore the feasibility of Dual-Energy Computed Tomography (DECT) in distinguishing metastatic from non-metastatic lymph nodes (LNs) in ovarian High-Grade Serous Carcinoma (HGSC), and to assess the incremental diagnostic value of combining DECT with morphologic parameters in differentiating metastatic and non-metastatic LNs. From October 2021 to May 2024, 141 LNs from 39 patients with HGSC who underwent DECT were retrospectively enrolled. LNs were matched with the pathological report. Five morphologic parameters and nine DECT parameters were assessed. DECT parameters were obtained from both the arterial and venous phases, including the attenuation at 40 and 70 keV, slope of the spectral Hounsfield unit curve (λ 86 metastatic LNs and 55 non-metastatic LNs were finally enrolled in our study. The short diameter (S), long diameter (L), and S/L ratio were significantly larger in metastatic LNs compared to non-metastatic LNs (9.69 ± 4.06 vs. 6.37 ± 1.24 mm, P < 0.001; 13.99 ± 5.36 vs.9.61 ± 2.30 mm, P < 0.001; 0.70 ± 0.15 vs. 0.67 ± 0.12, P = 0.023). In the venous phase, λ DECT parameters provide incremental diagnostic value in assessing metastatic LNs in patients with HGSC. The combination of the morphology and DECT models significantly improves diagnostic performance compared to the standalone morphology model.