Human papillomavirus-mediated expression of complement regulatory proteins in human cervical cancer cells

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doi:10.1016/j.ejogrb.2023.07.014

Human papillomavirus-mediated expression of complement regulatory proteins in human cervical cancer cells

Asiya Khan & Rashmi Kaul et al. · 2023-07-26

5Citations

This study aimed to evaluate the expression pattern of complement regulatory proteins (CRPs) CD46, CD59, and CD55 in HPV-positive (HPV We analysed the expression of CRPs in HPV 16-positive SiHa cell line, HPV 18-positive HeLa cell line, and HPV-negative cell line C33a using RT-qPCR, Western blotting, flow cytometry, and confocal microscopy. We observed a differential expression profile of CRPs in HPV The study demonstrates the differential expression of CRPs in both HPV

Links

DOI PubMed

Journal

European Journal of Obstetrics & Gynecology and Reproductive Biology

TL;DR

The study demonstrates the differential expression of CRPs in both HPV+ and HPV- cervical cancer cells for the first time, and their potential to serve as an early diagnostic marker for cervical carcinogenesis.

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Authors

Asiya Khan, Showket Hussain, Janaki K. Iyer, Anil Kaul, Mackenzie Bonnewitz, Rashmi Kaul