A combination of salinomycin or its C20 triphenylphosphonium-conjugated derivative with carboplatin leads to autophagy in ovarian cancer cells – An in vitro study
Ovarian cancer (OvCa) remains a major therapeutic challenge due to limited treatment options and frequent late-stage diagnosis, which contribute to high recurrence rates and mortality. Advances in synthetic organic chemistry and the development of novel oncology-targeted molecules offer promising new directions. In this study, we aimed to evaluate salinomycin (SAL) and its semisynthetic derivatives as potential candidates for OvCa therapy. Among the synthesized C20 SAL derivatives, we selected compound 8, featuring a triphenylphosphonium (TPP