Apatinib-loaded silicate nanoparticles coated with macrophage membranes and PD-1 antibody for enhanced chemo-immunotherapy in ovarian cancer via VEGFR2 and PD-1 dual inhibition

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doi:10.1016/j.colsurfb.2025.114790

Apatinib-loaded silicate nanoparticles coated with macrophage membranes and PD-1 antibody for enhanced chemo-immunotherapy in ovarian cancer via VEGFR2 and PD-1 dual inhibition

Hongru Li & Yuemei Jin et al. · 2025-05-14

1Citations

Ovarian cancer remains one of the most challenging malignancies to treat due to its aggressive nature and resistance to conventional therapies. In this study, we developed a nanoparticle-based system (Apa@SiO

Links

DOI PubMed

Journal

Colloids and Surfaces B: Biointerfaces

TL;DR

A nanoparticle-based system that combines chemotherapy with immune checkpoint inhibition for enhanced treatment of ovarian cancer and provides a promising multi-modal strategy for overcoming challenges in cancer therapy by integrating chemotherapy, immunotherapy, and targeted drug delivery.

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Authors

Hongru Li, Yuhan Wang, Shunqing Zhou, Jianli Liu, Yuemei Jin

Funding

Natural Science Foundation of Jilin Province Grant YDZJ202501ZYTS003 Natural Science Foundation of Jilin Province Grant YDZJ202401199ZYTS Jilin University Grant 2024B34