Eliminating Cervical Cancer: Progress and Challenges for High-income Countries
In 2020, the World Health Organization launched a major initiative to eliminate cervical cancer globally. The initiative is built around the three key pillars of human papillomavirus (HPV) vaccination, cervical screening and treatment, with associated intervention targets for the year 2030. The '90-70-90' targets specify that 90% of adolescent girls receive prophylactic HPV vaccination, 70% of adult women receive a minimum twice-in-a-lifetime cervical HPV test and 90% receive appropriate treatment for preinvasive or invasive disease. Modelling has shown that if these targets are met, the elimination of cervical cancer, defined as fewer than four cases per 100 000 women per annum, will be achieved within a century. Many high-income countries are well positioned to eliminate cervical cancer within the coming decades, but few have achieved '90-70-90' and many challenges must still be addressed to deliver these critical interventions effectively. This review considers the current status of cervical cancer control in relation to each of the three elimination pillars in high-income countries and discusses some of the developments that will assist countries in reaching these ambitious targets by 2030.
Journal
Clinical OncologyInstitutions
Authors
Funding
Cancer Research UK Manchester Centre Grant C19941/A28707Prognostic value of quantitative HPV viral load in determining cervical cancer treatment response and recurrenceCancer Research UK Manchester Centre Grant C147/A25254Department of Health Grant NIHR300650Cancer Research UK Grant 27859Cancer Research UK Manchester Centre Grant IS-BRC-1215-20007Cancer Research UK Manchester Centre Grant NIHR300650Cancer Research UK Manchester Centre Grant APP1159491Cancer Research UK Manchester Centre Grant APP1194679Cancer Research UK Manchester Centre Grant ECF181561Manchester Biomedical Research Centre Grant C147/A25254Manchester Biomedical Research Centre Grant IS-BRC-1215-20007Manchester Biomedical Research Centre Grant NIHR300650Manchester Biomedical Research Centre Grant APP1159491Manchester Biomedical Research Centre Grant APP1194679Manchester Biomedical Research Centre Grant ECF181561National Institute for Health Research Grant C147/A25254DH | National Institute for Health Research Grant IS-BRC-1215-20007National Institute for Health and Care Research (NIHR) Grant NIHR300650National Institute for Health Research Grant APP1159491National Institute for Health Research Grant APP1194679National Institute for Health Research Grant ECF181561Cancer Research UK Grant IS-BRC-1215-20007Cancer Research UK Grant NIHR300650Cancer Research UK Grant APP1159491Cancer Research UK Grant APP1194679Cancer Research UK Grant ECF181561National Health and Medical Research Council Grant C147/A25254National Health and Medical Research Council Grant IS-BRC-1215-20007National Health and Medical Research Council Grant NIHR300650National Health and Medical Research Council Grant APP1159491National Health and Medical Research Council Grant APP1194679National Health and Medical Research Council Grant ECF181561Cancer Institute NSW Grant C147/A25254Cancer Institute NSW Grant IS-BRC-1215-20007Cancer Institute NSW Grant NIHR300650Cancer Institute NSW Grant APP1159491Cancer Institute NSW Grant APP1194679Cancer Institute NSW Grant ECF181561