Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers

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doi:10.1016/j.cell.2021.07.005

Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers

Sridevi Challa & W. Lee Kraus et al. · 2021-07-26

Defects in translation lead to changes in the expression of proteins that can serve as drivers of cancer formation. Here, we show that cytosolic NAD

Links

DOI PubMed

Journal

Cell

Authors

Sridevi Challa, Beman R. Khulpateea, Tulip Nandu, Cristel V. Camacho, Keun W. Ryu, Hao Chen, Yan Peng, Jayanthi S. Lea, W. Lee Kraus

Funding

The Role of Nuclear PARPs in Signal-Regulated Transcription The Role of Nuclear PARPs in Signal-Regulated Transcription Ovarian Cancer Research Alliance Grant GAA202103-0003 The Role of Nuclear PARPs in Signal-Regulated Transcription National Institutes of Health Grant GAA202103-0003 The Role of Nuclear PARPs in Signal-Regulated Transcription Cecil H. and Ida Green Center for Reproductive Biology Sciences Grant GAA202103-0003 The Role of Nuclear PARPs in Signal-Regulated Transcription National Institute of Diabetes and Digestive and Kidney Diseases Grant GAA202103-0003 The Role of Nuclear PARPs in Signal-Regulated Transcription Ovarian Cancer Research Fund Alliance Grant GAA202103-0003

NIDDK NIH HHS

R01 DK069710

Ovarian Cancer Research Alliance

R01 DK069710

National Institutes of Health

R01 DK069710

Cecil H. and Ida Green Center for Reproductive Biology Sciences

R01 DK069710

National Institute of Diabetes and Digestive and Kidney Diseases

R01 DK069710

Ovarian Cancer Research Fund Alliance

R01 DK069710