Rapid prediction of cervical cancer and high-grade precursor lesions: An integrated approach using low-field 1H NMR and chemometric analysis

Luana Quadros de Souza Leão & Priscila Ferreira de Aquino et al. · 2025-05-05

4Citations
Cervical cancer (CC) is a significant cause of morbidity and mortality in women, often preceded by high-grade cervical intraepithelial lesions (HSIL). Although conventional cytology (Pap smear) is widely used for screening, its sensitivity limitations and high false-positive rate reinforce the need for complementary methods. This study investigated the feasibility of low-field
Links
DOIPubMed
Journal
Clinica Chimica Acta
TL;DR

Low-field 1H NMR spectroscopy combined with chemometric modeling is investigated to differentiate healthy individuals (CON) from patients with HSIL and CC, complementing traditional methods of early detection of tumors and cervical lesions.

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Authors
Luana Quadros de Souza Leão, Jelmir Craveiro de Andrade, Giovanna Melo Marques, Cristiane Cunha Guimarães, Rosyana de Fátima Vieira de Albuquerque, Alessandra Silva e Silva, Kamila Pereira de Araujo, Mikele Praia de Oliveira, Anderson Ferreira Gonçalves, Higino Felipe Figueiredo, Daniel Lourenço Lira, Marina Amaral Alves, Carlos Adam Conte-Junior, Priscila Ferreira de Aquino
Funding
Foundation for Research Support of Amazonas State Grant 213129/2020-1National Council for Scientific and Technological Development Grant 176168/2023-0 ]National Council for Scientific and Technological Development Grant 307846/2020-2Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro Grant E-26/200.738/2023Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro Grant E-26/201.534/2022Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro Grant E-26/201.296/2024Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro Grant E-26/201