YY1-glycolytic axis promotes high glucose-induced cancer stemness in endometrial cancer: A multi-omics guided therapeutic strategy

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doi:10.1016/j.canlet.2025.217936

YY1-glycolytic axis promotes high glucose-induced cancer stemness in endometrial cancer: A multi-omics guided therapeutic strategy

Xiao Yang & Jianliu Wang et al. · 2025-07-23

Abnormal glucose metabolism in patients with diabetes mellitus or hyperglycaemia is a key factor leading to poor prognosis of endometrial cancer (EC) and warrants further exploration of its underlying mechanisms. In this study, we employed an integrative multiomics approach, including proteomics, transcriptomics, nontargeted metabolomics and single-cell metabolomics, and revealed that high glucose promotes EC cell stemness, thereby promoting tumour progression and reducing the sensitivity of EC cells to cisplatin (platinum-Pt

Links

DOI PubMed

Journal

Cancer Letters

Authors

Xiao Yang, Chengcheng Li, Yuan Cheng, Shaojie Qin, Lingpu Zhang, Ling Zhou, Jingyi Zhou, Haihua Xiao, Yu Bai, Jianliu Wang

Funding

Natural Science Foundation of Beijing Municipality Grant Z240014 National Key Research and Development Program of China Grant 2022YFC3400700 National Key Research and Development Program of China Grant 2022YFC2704402 National Natural Science Foundation of China Grant 82203568 National Natural Science Foundation of China Grant 82230050 National Natural Science Foundation of China Grant 22125401 Peking University Grant RS2023-04 Peking University Grant RDJP2022-09