Single-cell transcriptomics reveals the aggressive landscape of high-grade serous carcinoma and therapeutic targets in tumor microenvironment

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doi:10.1016/j.canlet.2024.216928

Single-cell transcriptomics reveals the aggressive landscape of high-grade serous carcinoma and therapeutic targets in tumor microenvironment

Junfen Xu & Tianchen Guo et al. · 2024-05-05

High-grade serous carcinoma (HGSC) is characterized by early abdominal metastasis, leading to a dismal prognosis. In this study, we conducted single-cell RNA sequencing on 109,573 cells from 34 tumor samples of 18 HGSC patients, including both primary tumors and their metastatic sites. Our analysis revealed a distinct S100A9

Links

DOI PubMed

Journal

Cancer Letters

Authors

Junfen Xu, Weiguo Lu, Xinyi Wei, Bo Zhang, Haihua Yang, Mengyan Tu, Xin Chen, Shenglong Wu, Tianchen Guo