Labeling a TCO-functionalized single domain antibody fragment with 18F via inverse electron demand Diels Alder cycloaddition using a fluoronicotinyl moiety-bearing tetrazine derivative

Zhengyuan Zhou & Ganesan Vaidyanathan et al. · 2020-07-09

Single domain antibody fragments (sdAbs) exhibit a rapid tumor uptake and fast blood clearance amenable for labeling with

Links

Journal

Bioorganic & Medicinal Chemistry

Authors

Zhengyuan Zhou, Michael R. Zalutsky, Ganesan Vaidyanathan

Funding

Astatine And Iodine Radiolabeled Monoclonal Antibodies Labeling nanobodies with 18F residualizing labels for HER2 specific PET imaging Astatine and Iodine Radiolabeled Monoclonal Antibodies National Institutes of Health Funding

NCI NIH HHS

R01 CA042324

NCI NIH HHS

R01 CA188177

NCI NIH HHS

R37 CA042324