Human VH-antibody-based CAR T cells targeting folate receptor-alpha show enhanced persistence and reduced T-cell exhaustion against ovarian cancer

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Nithidol Sakunrangsit; Natapol Pornputtipong; Supannikar Tawinwung

doi:10.1016/j.biopha.2026.119169

Human VH-antibody-based CAR T cells targeting folate receptor-alpha show enhanced persistence and reduced T-cell exhaustion against ovarian cancer

Nithidol Sakunrangsit & Supannikar Tawinwung et al. · 2026-02-27

Folate receptor-alpha (FOLR1) is highly expressed in ovarian cancer and correlates with poor clinical outcomes, making it an attractive target for adoptive cell therapy. Single-domain antibodies (V We generated a second-generation FOLR1-specific CAR incorporating a fully human V Both V Human FOLR1-V

Human VH-antibody-based CAR T cells targeting folate receptor-alpha show enhanced persistence and reduced T-cell exhaustion against ovarian cancer

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