Cervical carcinoma high expressed 1 (CCHE1): An oncogenic lncRNA in diverse neoplasms
Recent studies have shown prominent role of long non-coding RNAs (lncRNAs) in the carcinogenesis process. These transcripts are flexible in the term of three dimensional conformations. This property endowed them the potential to have interaction with several biomolecules such as proteins, DNA or other RNAs. They control gene expression, cell differentiation, invasiveness of cancer cells and their metastatic ability. Dysregulation of these transcripts accounts for several disorders. They have particular application in cancer diagnosis and prediction of cancer course. Cervical Cancer High-Expressed lncRNA 1 (CCHE1) is an lncRNA which has been primarily identified during screening of differently expressed lncRNAs in cervical cancer. Being located in an intergenic area on chromosome 10, CCHE1 has been found to upregulate expression of proliferating cell nuclear antigen (PCNA) via binding with its mRNA, thus enhancing proliferation rate of cervical cancer cells. In addition to cervical cancer, CCHE1 contributes in the pathology of other types of cancers. In this paper, we discuss the role of CCHE1 the carcinogenic process in different tissues.