Icariside II suppresses cervical cancer cell migration through JNK modulated matrix metalloproteinase-2/9 inhibition in vitro and in vivo

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doi:10.1016/j.biopha.2020.110013

Icariside II suppresses cervical cancer cell migration through JNK modulated matrix metalloproteinase-2/9 inhibition in vitro and in vivo

Ya-Sai Sun & Zhao-Jun Wei et al. · 2020-02-25

Metastasis contributes a lot to cervical cancer high mortality rate. Icariside II is the principal component of Epimedium brevicornum Maxim and the major functional part to its therapeutic properties. However, the effects and mechanisms of Icariside II on cervical cancer metastasis remain unclear. Using female BALB/c mice with 60 mm

Links

DOI PubMed

Journal

Biomedicine & Pharmacotherapy

Authors

Ya-Sai Sun, Kiran Thakur, Fei Hu, Carlos L. Cespedes-Acuña, Jian-Guo Zhang, Zhao-Jun Wei

Funding

National Natural Science Foundation of China Grant 31850410476 Major Projects of Science and Technology in Anhui Province Grant 18030701142 Major Projects of Science and Technology in Anhui Province Grant 18030701158 Major Projects of Science and Technology in Anhui Province Grant 1804b06020347 Major Projects of Science and Technology in Anhui Province Grant 17030701028