Green synthesis and anti-tumor efficacy via inducing pyroptosis of novel 1H-benzo[e]indole-2(3H)-one spirocyclic derivatives

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doi:10.1016/j.bioorg.2023.106930

Green synthesis and anti-tumor efficacy via inducing pyroptosis of novel 1H-benzo[e]indole-2(3H)-one spirocyclic derivatives

Jianzhang Wu & Dulin Kong et al. · 2023-10-21

Pyroptosis induction is anticipated to be a new approach to developing anti-tumor medications. A novel class of spirocyclic compounds was designed by hybridization of 1H-Benzo[e]indole-2(3H)-one with 1,4-dihydroquinoline and synthesized through a new green "one-pot" synthesis method using 10 wt% SDS/H

Links

DOI PubMed

Journal

Bioorganic Chemistry

Authors

Jianzhang Wu, Xin Liu, Jie Zhang, Jiali Yao, Xiaolin Cui, Yaling Tang, Zixuan Xi, Meiting Han, Haoyu Tian, Yan Chen, Qiyun Fan, Wulan Li, Dulin Kong