SKLB-14b, a novel oral microtubule-destabilizing agent based on hydroxamic acid with potent anti-tumor and anti-multidrug resistance activities

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doi:10.1016/j.bioorg.2022.106053

SKLB-14b, a novel oral microtubule-destabilizing agent based on hydroxamic acid with potent anti-tumor and anti-multidrug resistance activities

Wanhua Zhang & Lijuan Chen et al. · 2022-08-01

A hydroxamic acid based microtubule-destabilizing agent (MDA) SKLB-14b was discovered in this study, which was derived from shortening the linker length of the HDAC6 and microtubule dual-target inhibitor SKLB-23bb. SKLB-14b exhibited low nanomolar IC

Links

DOI PubMed

Journal

Bioorganic Chemistry

Authors

Wanhua Zhang, Linyu Yang, Wenting Si, Minghai Tang, Peng Bai, Zejiang Zhu, Shuang Kuang, Jiang Liu, Mingsong Shi, Jinxing Huang, Xuanming Chen, Dan Li, Yi Wen, Zhuang Yang, Kai Xiao, Lijuan Chen

Funding

National Natural Science Foundation of China Grant 82073693 Sichuan University Grant 20HXBH174 Sichuan Province Science and Technology Support Program Grant 2020YJ0090 Sichuan Province Science and Technology Support Program Grant 2021YJ0417