Ovarian Cancer Risk Variants Are Enriched in Histotype-Specific Enhancers and Disrupt Transcription Factor Binding Sites
Quantifying the functional effects of complex disease risk variants can provide insights into mechanisms underlying disease biology. Genome-wide association studies have identified 39 regions associated with risk of epithelial ovarian cancer (EOC). The vast majority of these variants lie in the non-coding genome, where they likely function through interaction with gene regulatory elements. In this study we first estimated the heritability explained by known common low penetrance risk alleles for EOC. The narrow sense heritability (h
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Functional Effects of Ovarian Cancer Risk VariantsThe contribution of rare alleles to ovarian cancer in the populationDefining the epigenetic landscape in human prostate cancerGenomic and Transcriptomic Analysis of Breast and Ovarian CancersSoftware Tools For Regulatory Analysis of Large Cancer Methylome DatasetsIdentifying causal variants and genes underlying breast cancer risk lociAmerican Cancer Society Grant 134005Ovarian Cancer Research Alliance Grant 373356Ovarian Cancer Research Alliance Grant 599175National Institutes of Health Grant 5R0120745604Genomic and Transcriptomic Analysis of Breast and Ovarian CancersDefining the epigenetic landscape in human prostate cancerIdentifying causal variants and genes underlying breast cancer risk lociFunctional Effects of Ovarian Cancer Risk VariantsSoftware Tools For Regulatory Analysis of Large Cancer Methylome DatasetsThe contribution of rare alleles to ovarian cancer in the population