Photoacoustic/fluorescence dual-modality cyanine-based probe for real-time imaging of endogenous cysteine and in situ diagnosis of cervical cancer in vivo

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doi:10.1016/j.aca.2022.340713

Photoacoustic/fluorescence dual-modality cyanine-based probe for real-time imaging of endogenous cysteine and in situ diagnosis of cervical cancer in vivo

Xiang Zou & Weiying Lin et al. · 2022-12-09

17Citations

Cysteine (Cys), one of cellular biothiols in the organism, is associated with many diseases, such as Parkinson's disease, Alzheimer's disease, liver damage, rheumatoid arthritis, and cancer. However, activatable fluorescence/photoacoustic (FL/PA) probes for non-invasive, real-time, and deep imaging of Cys in vivo are still lacking, and this hinders the diagnosis of Cys-related diseases. Herein, we designed and synthesized a novel activated FL/PA dual-modality cyanine-base probe (FP

Links

DOI PubMed

Journal

Analytica Chimica Acta

TL;DR

A novel activated FL/PA dual-modality cyanine-base probe (FP700) has advantage of high potential for deep tumor diagnosis of Cys in vivo, which may provide a new approach for the detection of cervical cancer and identification of its potential therapeutic targets.

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Authors

Xiang Zou, Yuping Zhao, Weiying Lin

Funding

National Natural Science Foundation of China Grant 21877048 National Natural Science Foundation of China Grant 22077048 National Natural Science Foundation of China Grant 22277014 Natural Science Foundation of Guangxi Province Grant 2021GXNSFDA075003 Natural Science Foundation of Guangxi Province Grant AD21220061