Minimally invasive surgery and abdominal radical hysterectomy in patients with early‐stage cervical cancer: A meta‐analysis
Abstract
Objective
To compare risk of recurrence and death related to minimally invasive surgery (MIS) and abdominal radical hysterectomy (ARH) in early‐stage cervical cancer (CC) patients.
Methods
All relevant literatures in databases were retrieved from the built time of databases to October 2020. Observational studies comparing MIS and ARH in early‐stage CC patients were involved. Newcastle‐Ottawa Scale was used for quality assessment, including studies with a score of at least 6. Main outcomes involved overall survival (OS) and disease‐free survival (DFS).
Results
Twenty‐two studies were involved, including 14 894 patients, among which 7213 (48.6%) underwent MIS. The OS (hazard ratio [HR] 1.23, 95% confidence interval [CI] 1.03–1.43) and DFS (HR 1.25, 95% CI 1.07–1.42) of patients undergoing MIS was obviously shortened compared with those of patients undergoing ARH. Subgroup analysis revealed that OS (HR 1.42, 95% CI 1.10–1.74) and DFS (HR 1.46, 95% CI 1.18–1.74) of patients with a tumor ≥2 cm in diameter were significantly reduced by MIS.
Conclusion
Overall survival and DFS after MIS for early‐stage CC treatment were worse than those after ARH, especially for patients with a tumor ≥2 cm in diameter.