Risk factors for cervical stromal involvement in endometrioid‐type endometrial cancer
Abstract
Objective
The aim of this study was to identify predictors of cervical stromal involvement in women with endometrioid‐type endometrial cancer (EEC).
Methods
A total of 795 patients with EEC who underwent comprehensive surgical staging including pelvic and para‐aortic lymph node dissection between January 2007 and December 2018 were retrospectively analyzed. Data including age, menopausal status, serum CA‐125 levels, tumor size, lymphovascular space invasion (LVSI), depth of myometrial invasion, positive peritoneal cytology, cervical stromal involvement, histologic grade, recurrence, and follow‐up duration were recorded.
Results
Median follow up was 49 months. Cervical stromal invasion was found in 88 patients. Multivariate analysis revealed that presence of LVSI (hazard ratio [HR] 2, 95% confidence interval [CI] 1.02–4.25, P = 0.045), a primary tumor diameter of at least 3 cm (HR 3, 95% CI 1.31–7.25, P = 0.010), and at least 50% deep myometrial invasion (HR 2.7, 95% CI 1.37–5.41, P = 0.004) were independent risk factors for cervical stromal involvement in patients with EEC.
Conclusion
Our study results suggest that presence of LVSI, a primary tumor diameter of at least 3 cm, and LVSI of at least 50% seem to be independent predictors of cervical involvement in women with EEC.