Ovarian cancer onset across different BRCA mutation types: a view to a more tailored approach for BRCA mutated patients
To evaluate the role of different specific types of germline breast cancer susceptibility This was a multicenter, international, retrospective cohort of 474 patients diagnosed with recurrent or newly diagnosed high grade serous ovarian cancer, with known germline mutations in Excluding the 29 patients with a splicing mutation, 474 patients were enrolled: 309 (65.2%) with frameshift mutations, 102 (21.5%) with nonsense mutations, and 63 (13.3%) with missense mutations. The Different types of germline