A novel CSN5/CRT O-GlcNAc/ER stress regulatory axis in platinum resistance of epithelial ovarian cancer

Tianqing Yan & Renquan Lu et al. · 2024-01-27

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TL;DR

It is revealed that CSN5-mediated aberrant O-GlcNAc-CRT acts as a crucial ER stress checkpoint, governing cell fate response to stress, and emphasizes an unrecognized role for the CSN5/CRT O-GlcNAc/ER stress axis in platinum resistance of EOC.

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Authors
Tianqing Yan, Xiaolu Ma, Kaixia Zhou, Jiazhen Cao, Yanan Tian, Hui Zheng, Ying Tong, Suhong Xie, Yanchun Wang, Lin Guo, Renquan Lu