Triptonide-mediated PTGS2 Inhibition Induces Autophagic Cell Death to Suppress the Progression of Triple-negative Breast Cancer and Epithelial Ovarian Cancer

Kunxiang Gong & Yinger Huang et al. · 2026-01-30

TL;DR

TN is identified as a promising candidate for TNBC and EOC treatment, acting through a novel mechanism involving targeted degradation of PTGS2 protein, acting through a novel mechanism involving targeted degradation of PTGS2 protein.

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Authors
Kunxiang Gong, Kai Song, Haotian Wang, Linye Li, Xiaomin Sun, Lingling Sun, Wenbo Hao, Zhe-Sheng Chen, Yinger Huang