FBXW7 Directly Ubiquitinates and Degrades CTNNB1 Mediating the Suppression of ENKUR in Endometrial Cancer

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doi:10.7150/ijbs.104067

FBXW7 Directly Ubiquitinates and Degrades CTNNB1 Mediating the Suppression of ENKUR in Endometrial Cancer

YaHui Liu & SuiQun Guo et al. · 2025-02-10

3Citations

Enkurin (ENKUR) is a tumor suppressor in some malignancies. However, its role in endometrial cancer (EC) remains unknown. Here, we firstly observed that reduced ENKUR expression promotes progression and poor prognosis in EC. Moreover,the overexpression of ENKUR suppressed the proliferation, migration, invasion, and intrahepatic dissemination of EC

Links

DOI PubMed

Journal

International Journal of Biological Sciences

TL;DR

It is observed that reduced ENKUR expression promotes progression and poor prognosis in endometrial cancer (EC), and ENKUR may be a tumor suppressor via recruiting FBXW7 to directly ubiquitinate and degrade CTNNB1 in EC.

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Authors

YaHui Liu, Qian Wang, QiRun Guo, Ying Zhu, Li Lin, ChunYan Yang, Bin Gong, Weiwei Yan, RenTao Hou, Yao Tang, XiuQiong Wu, Xinhui Liu, BeiXian Zhou, WeiYi Fang, LuYun Shu, SuiQun Guo