Investigating the Spatial Distribution of Proliferating Cells in Primary Ovarian Cancers
Ovarian cancer (OC) accounts for about 4% of female cancers globally. While Ki67-immunopositive (Ki67 A total of 100 tissue cores, included in a tissue microarray (TMA) representing 5 clear cell carcinomas, 62 serous carcinomas, 10 mucinous adenocarcinomas, 3 endometrioid adenocarcinomas, 10 lymph node metastases from OC, and 10 samples of adjacent normal ovary tissue, were stained using a standardized immunohistochemical protocol. The computer-aided image analysis system assessed the 2D distribution pattern of Ki67 Significant differences in Ki67 Cell proliferation is a hallmark of OCs. This study provides new evidence that investigating the Ki67