Tiny plastic, big trouble: how polystyrene nanoparticles impact DNA-damage repair deficient cervical cancer cells

Jordan D. Berezowitz & Brittany E. Givens · 2026-02-18

Colloidal stability of micro- and nano-plastics influences interactions with human cells. These effects can be measured as a function of DNA damage repair via mitochondrial function, esterase activity, and oxidative stress.

Links
DOIPubMed
Journal
Soft Matter
TL;DR

Results indicate that high concentrations of polystyrene are required to elicit toxicological effects in cervical cells within 24 hours, particularly in esterase activity measured with calcein AM.

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Institutions
University Of Kentucky
Authors
Jordan D. Berezowitz, Brittany E. Givens
Funding
Center for Appalachian Research in Environmental Sciences-Community Engagement Core (CEC)Center for Appalachian Research in Environmental Sciences-Community Engagement Core (CEC)Division of Engineering Education and Centers Grant 2150337

NIEHS NIH HHS

P30 ES026529

National Institute of Environmental Health Sciences

P30 ES026529