Smear detected cervicovaginal melanoma following negative screening—a cautionary tale of rapidly developing malignancy of the lower female genital tract

Joshua J. X. Li · 2021-08-27

2Citations

Cervicovaginal melanoma is a rare and aggressive neoplasm detectable by Pap smear. Non‐HPV‐related lesions, such as melanoma, can be rapidly progressive and unsuspected. Awareness of uncommon but clinically significant lesions on Pap smear is important.

TL;DR

The Pap smear is a robust tool for detection of cervical intraepithelial lesions and primary cervical carcinomas and shows the best interobserver agreement in the negative for intraepIthelial lesion (NILM), low-grade squamous intraepsithelial lesions (LSIL), high-gradeSquamous intraepIThelialLesion (HSIL) and squamous cell carcinoma (SCC) diagnostic categories.

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