The Impact of BRCA Mutation on the Efficacy of Neoadjuvant Chemotherapy in Advanced Ovarian Cancer
this retrospective study aimed to evaluate the impact of BRCA mutational status on the outcomes of patients with advanced ovarian cancer treated with either primary debulking surgery (PDS) or neoadjuvant chemotherapy followed by interval debulking surgery (NACT-IDS). Material and BRCA mutational status is a critical factor influencing survival outcomes in advanced ovarian cancer. While BRCAwt patients may slightly benefit from PDS, BRCAmut patients exhibit significantly improved OS with NACT-IDS. These findings support the need for individualized treatment strategies based on BRCA status to optimize outcomes in ovarian cancer.