Recent Developments on the Roles of Calcium Signals and Potential Therapy Targets in Cervical Cancer
Intracellular calcium (Ca2+) concentration ([Ca2+]i) is implicated in proliferation, invasion, and metastasis in cancerous tissues. A variety of oncologic therapies and some candidate drugs induce their antitumor effects (in part or in whole) through the modulation of [Ca2+]i. Cervical cancer is one of most common cancers among women worldwide. Recently, major research advances relating to the Ca2+ signals in cervical cancer are emerging. In this review, we comprehensively describe the current progress concerning the roles of Ca2+ signals in the occurrence, development, and prognosis of cervical cancer. It will enhance our understanding of the causative mechanism of Ca2+ signals in cervical cancer and thus provide new sights for identifying potential therapeutic targets for drug discovery.
Journal
CellsAuthors
Funding
Ministry of Science and Technology Grant 2019YFA0802600Ministry of Science and Technology Grant 82271724Ministry of Science and Technology Grant 81873841Ministry of Science and Technology Grant 81741024Ministry of Science and Technology Grant 81401244Ministry of Science and Technology Grant GSWS2019029Ministry of Science and Technology Grant SLJ202012Ministry of Science and Technology Grant SLT202003Ministry of Science and Technology Grant BE2018669Ministry of Science and Technology Grant M2021087Ministry of Science and Technology Grant BK20221243National Nature and Science Foundation of China Grant 2019YFA0802600National Nature and Science Foundation of China Grant 82271724National Nature and Science Foundation of China Grant 81873841National Nature and Science Foundation of China Grant 81741024National Nature and Science Foundation of China Grant 81401244National Nature and Science Foundation of China Grant GSWS2019029National Nature and Science Foundation of China Grant SLJ202012National Nature and Science Foundation of China Grant SLT202003National Nature and Science Foundation of China Grant BE2018669National Nature and Science Foundation of China Grant M2021087National Nature and Science Foundation of China Grant BK20221243Suzhou City “Wei Sheng Ren Cai (GSWS2019029)” program Grant 2019YFA0802600Suzhou City “Wei Sheng Ren Cai (GSWS2019029)” program Grant 82271724Suzhou City “Wei Sheng Ren Cai (GSWS2019029)” program Grant 81873841Suzhou City “Wei Sheng Ren Cai (GSWS2019029)” program Grant 81741024Suzhou City “Wei Sheng Ren Cai (GSWS2019029)” program Grant 81401244Suzhou City “Wei Sheng Ren Cai (GSWS2019029)” program Grant GSWS2019029Suzhou City “Wei Sheng Ren Cai (GSWS2019029)” program Grant SLJ202012Suzhou City “Wei Sheng Ren Cai (GSWS2019029)” program Grant SLT202003Suzhou City “Wei Sheng Ren Cai (GSWS2019029)” program Grant BE2018669Suzhou City “Wei Sheng Ren Cai (GSWS2019029)” program Grant M2021087Suzhou City “Wei Sheng Ren Cai (GSWS2019029)” program Grant BK20221243Medical and Industrial Integration Collaborative Innovation Research Project Grant 2019YFA0802600Medical and Industrial Integration Collaborative Innovation Research Project Grant 82271724Medical and Industrial Integration Collaborative Innovation Research Project Grant 81873841Medical and Industrial Integration Collaborative Innovation Research Project Grant 81741024Medical and Industrial Integration Collaborative Innovation Research Project Grant 81401244Medical and Industrial Integration Collaborative Innovation Research Project Grant GSWS2019029Medical and Industrial Integration Collaborative Innovation Research Project Grant SLJ202012Medical and Industrial Integration Collaborative Innovation Research Project Grant SLT202003Medical and Industrial Integration Collaborative Innovation Research Project Grant BE2018669Medical and Industrial Integration Collaborative Innovation Research Project Grant M2021087Medical and Industrial Integration Collaborative Innovation Research Project Grant BK20221243Clinical Trial Institution Capacity Enhancement Project Grant 2019YFA0802600Clinical Trial Institution Capacity Enhancement Project Grant 82271724Clinical Trial Institution Capacity Enhancement Project Grant 81873841Clinical Trial Institution Capacity Enhancement Project Grant 81741024Clinical Trial Institution Capacity Enhancement Project Grant 81401244Clinical Trial Institution Capacity Enhancement Project Grant GSWS2019029Clinical Trial Institution Capacity Enhancement Project Grant SLJ202012Clinical Trial Institution Capacity Enhancement Project Grant SLT202003Clinical Trial Institution Capacity Enhancement Project Grant BE2018669Clinical Trial Institution Capacity Enhancement Project Grant M2021087Clinical Trial Institution Capacity Enhancement Project Grant BK20221243Jiangsu provincial key research and development plan of science and technology department Grant 2019YFA0802600Jiangsu provincial key research and development plan of science and technology department Grant 82271724Jiangsu provincial key research and development plan of science and technology department Grant 81873841Jiangsu provincial key research and development plan of science and technology department Grant 81741024Jiangsu provincial key research and development plan of science and technology department Grant 81401244Jiangsu provincial key research and development plan of science and technology department Grant GSWS2019029Jiangsu provincial key research and development plan of science and technology department Grant SLJ202012Jiangsu provincial key research and development plan of science and technology department Grant SLT202003Jiangsu provincial key research and development plan of science and technology department Grant BE2018669Jiangsu provincial key research and development plan of science and technology department Grant M2021087Jiangsu provincial key research and development plan of science and technology department Grant BK20221243General Programs of Jiangsu Commission of Health Grant 2019YFA0802600General Programs of Jiangsu Commission of Health Grant 82271724General Programs of Jiangsu Commission of Health Grant 81873841General Programs of Jiangsu Commission of Health Grant 81741024General Programs of Jiangsu Commission of Health Grant 81401244General Programs of Jiangsu Commission of Health Grant GSWS2019029”General Programs of Jiangsu Commission of Health Grant SLJ202012General Programs of Jiangsu Commission of Health Grant SLT202003General Programs of Jiangsu Commission of Health Grant BE2018669General Programs of Jiangsu Commission of Health Grant M2021087General Programs of Jiangsu Commission of Health Grant BK20221243Nature and Science Foundation of Jiangsu Grant 2019YFA0802600Nature and Science Foundation of Jiangsu Grant 82271724Nature and Science Foundation of Jiangsu Grant 81873841Nature and Science Foundation of Jiangsu Grant 81741024Nature and Science Foundation of Jiangsu Grant 81401244Nature and Science Foundation of Jiangsu Grant GSWS2019029Nature and Science Foundation of Jiangsu Grant SLJ202012Nature and Science Foundation of Jiangsu Grant SLT202003Nature and Science Foundation of Jiangsu Grant BE2018669Nature and Science Foundation of Jiangsu Grant M2021087Nature and Science Foundation of Jiangsu Grant BK20221243