Recent Developments on the Roles of Calcium Signals and Potential Therapy Targets in Cervical Cancer

Jiahui Lei & Qinqin Gao et al. · 2022-09-26

Intracellular calcium (Ca2+) concentration ([Ca2+]i) is implicated in proliferation, invasion, and metastasis in cancerous tissues. A variety of oncologic therapies and some candidate drugs induce their antitumor effects (in part or in whole) through the modulation of [Ca2+]i. Cervical cancer is one of most common cancers among women worldwide. Recently, major research advances relating to the Ca2+ signals in cervical cancer are emerging. In this review, we comprehensively describe the current progress concerning the roles of Ca2+ signals in the occurrence, development, and prognosis of cervical cancer. It will enhance our understanding of the causative mechanism of Ca2+ signals in cervical cancer and thus provide new sights for identifying potential therapeutic targets for drug discovery.

Links
DOIPubMed
Journal
Cells
Authors
Jiahui Lei, Fengying Deng, Hongmei Ding, Mengyu Fu, Ting Xu, Bingyu Ji, Lin Feng, Min Li, Junlan Qiu, Qinqin Gao
Funding

Ministry of Science and Technology

2019YFA0802600

Ministry of Science and Technology

82271724

Ministry of Science and Technology

81873841

Ministry of Science and Technology

81741024

Ministry of Science and Technology

81401244

Ministry of Science and Technology

GSWS2019029

Ministry of Science and Technology

SLJ202012

Ministry of Science and Technology

SLT202003

Ministry of Science and Technology

BE2018669

Ministry of Science and Technology

M2021087

Ministry of Science and Technology

BK20221243

National Nature and Science Foundation of China

2019YFA0802600

National Nature and Science Foundation of China

82271724

National Nature and Science Foundation of China

81873841

National Nature and Science Foundation of China

81741024

National Nature and Science Foundation of China

81401244

National Nature and Science Foundation of China

GSWS2019029

National Nature and Science Foundation of China

SLJ202012

National Nature and Science Foundation of China

SLT202003

National Nature and Science Foundation of China

BE2018669

National Nature and Science Foundation of China

M2021087

National Nature and Science Foundation of China

BK20221243

Suzhou City “Wei Sheng Ren Cai (GSWS2019029)” program

2019YFA0802600

Suzhou City “Wei Sheng Ren Cai (GSWS2019029)” program

82271724

Suzhou City “Wei Sheng Ren Cai (GSWS2019029)” program

81873841

Suzhou City “Wei Sheng Ren Cai (GSWS2019029)” program

81741024

Suzhou City “Wei Sheng Ren Cai (GSWS2019029)” program

81401244

Suzhou City “Wei Sheng Ren Cai (GSWS2019029)” program

GSWS2019029

Suzhou City “Wei Sheng Ren Cai (GSWS2019029)” program

SLJ202012

Suzhou City “Wei Sheng Ren Cai (GSWS2019029)” program

SLT202003

Suzhou City “Wei Sheng Ren Cai (GSWS2019029)” program

BE2018669

Suzhou City “Wei Sheng Ren Cai (GSWS2019029)” program

M2021087

Suzhou City “Wei Sheng Ren Cai (GSWS2019029)” program

BK20221243

Medical and Industrial Integration Collaborative Innovation Research Project

2019YFA0802600

Medical and Industrial Integration Collaborative Innovation Research Project

82271724

Medical and Industrial Integration Collaborative Innovation Research Project

81873841

Medical and Industrial Integration Collaborative Innovation Research Project

81741024

Medical and Industrial Integration Collaborative Innovation Research Project

81401244

Medical and Industrial Integration Collaborative Innovation Research Project

GSWS2019029

Medical and Industrial Integration Collaborative Innovation Research Project

SLJ202012

Medical and Industrial Integration Collaborative Innovation Research Project

SLT202003

Medical and Industrial Integration Collaborative Innovation Research Project

BE2018669

Medical and Industrial Integration Collaborative Innovation Research Project

M2021087

Medical and Industrial Integration Collaborative Innovation Research Project

BK20221243

Clinical Trial Institution Capacity Enhancement Project

2019YFA0802600

Clinical Trial Institution Capacity Enhancement Project

82271724

Clinical Trial Institution Capacity Enhancement Project

81873841

Clinical Trial Institution Capacity Enhancement Project

81741024

Clinical Trial Institution Capacity Enhancement Project

81401244

Clinical Trial Institution Capacity Enhancement Project

GSWS2019029

Clinical Trial Institution Capacity Enhancement Project

SLJ202012

Clinical Trial Institution Capacity Enhancement Project

SLT202003

Clinical Trial Institution Capacity Enhancement Project

BE2018669

Clinical Trial Institution Capacity Enhancement Project

M2021087

Clinical Trial Institution Capacity Enhancement Project

BK20221243

Jiangsu provincial key research and development plan of science and technology department

2019YFA0802600

Jiangsu provincial key research and development plan of science and technology department

82271724

Jiangsu provincial key research and development plan of science and technology department

81873841

Jiangsu provincial key research and development plan of science and technology department

81741024

Jiangsu provincial key research and development plan of science and technology department

81401244

Jiangsu provincial key research and development plan of science and technology department

GSWS2019029

Jiangsu provincial key research and development plan of science and technology department

SLJ202012

Jiangsu provincial key research and development plan of science and technology department

SLT202003

Jiangsu provincial key research and development plan of science and technology department

BE2018669

Jiangsu provincial key research and development plan of science and technology department

M2021087

Jiangsu provincial key research and development plan of science and technology department

BK20221243

General Programs of Jiangsu Commission of Health

2019YFA0802600

General Programs of Jiangsu Commission of Health

82271724

General Programs of Jiangsu Commission of Health

81873841

General Programs of Jiangsu Commission of Health

81741024

General Programs of Jiangsu Commission of Health

81401244

General Programs of Jiangsu Commission of Health

GSWS2019029

General Programs of Jiangsu Commission of Health

SLJ202012

General Programs of Jiangsu Commission of Health

SLT202003

General Programs of Jiangsu Commission of Health

BE2018669

General Programs of Jiangsu Commission of Health

M2021087

General Programs of Jiangsu Commission of Health

BK20221243

Nature and Science Foundation of Jiangsu

2019YFA0802600

Nature and Science Foundation of Jiangsu

82271724

Nature and Science Foundation of Jiangsu

81873841

Nature and Science Foundation of Jiangsu

81741024

Nature and Science Foundation of Jiangsu

81401244

Nature and Science Foundation of Jiangsu

GSWS2019029

Nature and Science Foundation of Jiangsu

SLJ202012

Nature and Science Foundation of Jiangsu

SLT202003

Nature and Science Foundation of Jiangsu

BE2018669

Nature and Science Foundation of Jiangsu

M2021087

Nature and Science Foundation of Jiangsu

BK20221243