Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis not only characterised by rapidly progressive skin ulceration, often triggered by trauma or surgery, but also associated with malignancy as a paraneoplastic condition. This case report describes a female patient in her early 70s who developed PG following a total abdominal hysterectomy, bilateral salpingo-oophorectomy and omentectomy for stage IVB high-grade serous carcinoma of the endometrium. This case highlights the diagnostic challenges, the role of early multidisciplinary involvement, investigation and appropriate therapeutic interventions.