Senolytic Elimination of Senescent Ovarian Clear Cell Carcinoma Cells Induced by CEP-1347 With the BH3 Mimetic Navitoclax

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doi:10.21873/anticanres.17832

Senolytic Elimination of Senescent Ovarian Clear Cell Carcinoma Cells Induced by CEP-1347 With the BH3 Mimetic Navitoclax

YASUFUMI ITO & MASASHI OKADA et al.

Ovarian clear cell carcinoma (OCCC) is a subtype of epithelial ovarian cancer characterized by infrequent Senescence-like phenotypes were analyzed using microscopy, flow cytometry, and western blotting. Combined effects with senolytics were evaluated using cell death assays, colony formation assays, and western blot analysis. CEP-1347 induced cellular senescence in OCCC cells with wild-type CEP-1347 induced cellular senescence in OCCC cells with wild-type

Links

DOI PubMed

Journal

Anticancer Research

Authors

YASUFUMI ITO, KAZUKI NAKAMURA, YURIKA NAKAGAWA-SAITO, SENRI TAKENOUCHI, SHUHEI SUZUKI, KEITA TOGASHI, ASUKA SUGAI, YUTA MITOBE, MANABU SEINO, TSUYOSHI OHTA, SATORU NAGASE, CHIFUMI KITANAKA, MASASHI OKADA