Circ_0031027 adjusts the advancement of cervical cancer by miR‐587/SOCS5 axis
Abstract
Background
Circular RNAs (circRNAs) might participate in the growth of cervical cancer (CC). In this research, we reconnoitered the characters of circ_0031027 in CC.
Methods
Circ_0031027, microRNA‐587 (miR‐587), and suppressor of cytokine signaling 5 (SOCS5) abundances were distinguished by qRT‐PCR and western blot. The cell functions were examined by colony formation assay, EdU assay, and transwell assay. The combined relationship of miR‐587 and circ_0031027 or SOCS5 was identified by dual‐luciferase reporter assay. Ultimately, the mice test was utilized to assess the part of circ_0031027.
Results
Circ_0031027 and SOCS5 were downregulated, and the miR‐587 was upregulated in CC. For functional analysis, circ_0031027 overexpression repressed cell proliferation, cell migration, and invasion in CC cells. Circ_0031027 as a miR‐587 sponge to adjust SOCS5. MiR‐587 facilitated the advancement of CC cells by overturning SOCS5. In addition, circ_0031027 overexpression subdued tumor growth.
Conclusion
Circ_0031027 inhibited the enlargement of CC by miR‐587/SOCS5.