NOTCH2 gene mutation and gamma-secretase inhibitor in mediating the malignancy of ovarian cancer

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doi:10.18632/aging.205045

NOTCH2 gene mutation and gamma-secretase inhibitor in mediating the malignancy of ovarian cancer

Wenjing Wang & Dan Su et al. · 2023-09-19

3Citations

The carcinogenic mechanisms by which serous ovarian cancer (OC) occurs remain to be explored. Currently, we have conducted whole-exome sequencing (WES) and targeted deep sequencing to validate new molecular markers, including

Links

DOI PubMed

Journal

Aging

TL;DR

Western blotting confirmed that NOTCH2-mediated tumorigenesis lies in reducing apoptosis through dysregulation of Bax/Bcl2, affecting repair of DNA damage through reducing DNA-PK and blocking the transcription factor Hes1 along with increasing immune regulator p65.

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Authors

Wenjing Wang, Ruiqian Liu, Wei Liao, Landie Ji, Jie Mei, Dan Su