Cancer Cell Membrane-Enveloped Dexamethasone Normalizes the Tumor Microenvironment and Enhances Gynecologic Cancer Chemotherapy

Huapan Fang · 2023-08-21

39Citations
2Influential
The aberrant tumor microenvironment (TME), especially immature and leaky vessels, prevents the penetration and accumulation of chemotherapeutics and results in the failure of chemotherapy to treat gynecologic cancer. Herein, dexamethasone (Dex), a glucocorticoid steroid used to moderate tumor extracellular matrix and normalize vessels, was enclosed within a biocompatible material known as poly(lactic-
Links
DOIPubMed
Journal
ACS Nano
TL;DR

The formulated Dex@PLGA-CM nanoparticles greatly reshaped the TME, enhancing the penetration of Doxil and thus markedly improving the therapeutic effect of this drug against cervical cancers.

AI-generated by Semantic Scholar

Institutions
Xiamen University
Authors
Huapan Fang
Funding
Jiangsu Province Postdoctoral Science Foundation Grant 2021K355CChina Postdoctoral Science Foundation Grant 2020M681708National Natural Science Foundation of China Grant 52203183Program of Shanghai Academic Research Leader Grant 22XD1403500Shanghai Municipal Key Clinical Specialty Grant shslczdzk06302Central Guidance on Local Science and Technology Development Fund of Shanghai Province Grant YDZX20223100003006