Umbilical Cord Blood-Derived M1 Macrophage Exosomes Loaded with Cisplatin Target Ovarian Cancer In Vivo and Reverse Cisplatin Resistance

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doi:10.1021/acs.molpharmaceut.3c00132

Umbilical Cord Blood-Derived M1 Macrophage Exosomes Loaded with Cisplatin Target Ovarian Cancer In Vivo and Reverse Cisplatin Resistance

Xiaohui Zhang & Xiaoqing Guo et al. · 2023-10-11

We investigated the therapeutic efficacy of umbilical cord blood (UCB)-derived M1 macrophage exosomes loaded with cisplatin (CIS) in ovarian cancer and platinum resistance. M1 macrophages were purified by using CD14 magnetic beads and characterized by flow cytometry. Our analyses included morphology, particle size, particle concentration, potential, drug loading capacity, counts of entry into cells, antitumor effect

Links

DOI PubMed

Journal

Molecular Pharmaceutics

Authors

Xiaohui Zhang, Jiapo Wang, Na Liu, Weimin Wu, Hong Li, Wen Lu, Xiaoqing Guo

Funding

National Natural Science Foundation of China Grant 81602278