The Multiomics Landscape of Plasma-Derived Small Extracellular Vesicles during the Development of HPV+ Cervical Cancer

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Shizhi Wang

doi:10.1021/acs.jproteome.5c00304

The transition from HPV infection to cervical cancer (CC) remains unclear, especially concerning small extracellular vesicles (sEVs). We analyzed plasma-sEVs from HPV-negative individuals (HPVN-sEVs), HPV-positive individuals (HPVP-sEVs), and HPV-positive CC patients (HPVC-sEVs) via proteomics (n = 5/5/9) and transcriptomics (n = 3/3/4). Multiomics revealed HPVP-sEVs harbor antiviral and pro-inflammatory signals early in infection, whereas HPVC-sEVs shift toward immunosuppression to sustain persistent infection. Specifically, IFITM2─an antiviral gene─was markedly enriched in HPVP-sEVs versus HPVN-sEVs (

The Multiomics Landscape of Plasma-Derived Small Extracellular Vesicles during the Development of HPV⁺ Cervical Cancer

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