Acetogenins from the Stem of Uvaria rufa and Their Cytotoxic Activity

Aleksandra Gurgul & Joanna E. Burdette et al. · 2024-01-18

4Citations
Four new adjacent bis-tetrahydrofuran acetogenins, bullacin C (
Links
DOIPubMed
Journal
Journal of Natural Products
TL;DR

Most tested acetogenins exhibited cytotoxicity against human cancer cell lines (HCT 116, 22Rv1, MDA-MB-435, OVCAR3), and Squamocin and uvarirufin were found to be the most potent, with an IC50 value of 1.2 μM for both in HCT 116 colon cancer cells.

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Institutions
University Of Illinois Chicago
Authors
Aleksandra Gurgul, Manead Khin, Joanna E. Burdette
Funding
Project 3:Isolation Chemistry of Filamentous Fungi and Biological EvaluationDefining the role of isoprenylated xanthones from the mangosteen for enhancing degradation of full length and variant forms of androgen receptor in prostate cancerDefining the role of isoprenylated xanthones from the mangosteen for enhancing degradation of full length and variant forms of androgen receptor in prostate cancerProject 3:Isolation Chemistry of Filamentous Fungi and Biological EvaluationUniversity of Illinois at Chicago: University Fellowship FundingCalifornia Community Foundation Fund Grant 155689

NCI NIH HHS

P01 CA125066

NCI NIH HHS

R37 CA227101

National Institutes of Health

R37 CA227101

National Institutes of Health

P01CA125066