Discovery of Novel Azaphenothiazine Derivatives to Suppress Endometrial Cancer by Targeting GRP75 to Impair Its Interaction with IP3R and Mitochondrial Ca2+ Homeostasis

Jian Li & Fei Mao · 2024-07-31

Endometrial cancer (EC) is the most common cancer of the female reproductive tract, and there is an urgent need to develop new candidate drugs with good efficacy and safety to improve the survival rate and life quality of EC patients. Herein, a series of new azaphenothiazine derivatives were designed and synthesized and their anti-EC activities were evaluated. Among them, compound
Links
DOIPubMed
Journal
Journal of Medicinal Chemistry
Institutions
East China University Of Science And TechnologyUnknown Institution
Authors
Jian Li, Fei Mao
Funding

Natural Science Foundation of Shanghai Municipality

20ZR1414800

National Key Research and Development Program of China

2021YFA0804904

State Key Laboratory of Bioreactor Engineering

2060204

National Natural Science Foundation of China

22077033

Program of Shanghai Academic Research Leader

22XD1403500

Innovative Research Team of High-level Local Universities in Shanghai

SHSMU-ZDCX20212702

Shanghai Frontier Science Center of Optogenetic Techniques for Cell Metabolism

SHSMU-ZDCX20212702

Central Guidance on Local Science and Technology Development Fund of Shanghai Province

YDZX20223100003006