Discovery of Novel Azaphenothiazine Derivatives to Suppress Endometrial Cancer by Targeting GRP75 to Impair Its Interaction with IP3R and Mitochondrial Ca2+ Homeostasis
Endometrial cancer (EC) is the most common cancer of the female reproductive tract, and there is an urgent need to develop new candidate drugs with good efficacy and safety to improve the survival rate and life quality of EC patients. Herein, a series of new azaphenothiazine derivatives were designed and synthesized and their anti-EC activities were evaluated. Among them, compound
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Funding
Natural Science Foundation of Shanghai Municipality Grant 20ZR1414800National Key Research and Development Program of China Grant 2021YFA0804904State Key Laboratory of Bioreactor Engineering Grant 2060204National Natural Science Foundation of China Grant 22077033Program of Shanghai Academic Research Leader Grant 22XD1403500Innovative Research Team of High-level Local Universities in Shanghai Grant SHSMU-ZDCX20212702Shanghai Frontier Science Center of Optogenetic Techniques for Cell Metabolism Grant SHSMU-ZDCX20212702Central Guidance on Local Science and Technology Development Fund of Shanghai Province Grant YDZX20223100003006