Making Protein Degradation Visible: Discovery of Theranostic PROTACs for Detecting and Degrading NAMPT

· 2022-11-28

Proteolysis-targeting chimera (PROTAC) is emerging as a promising technology in targeted protein degradation and drug discovery. However, there is still a lack of effective chemical tools to real-time detect and track the protein degradation. Herein, the first fluorescent and theranostic PROTACs were designed for imaging the degradation of nicotinamide phosphoribosyltransferase (NAMPT) in living cells. Compound
Funding

Ministry of Science and Technology of the People's Republic of China

2020YFA0509200

National Natural Science Foundation of China

81725020

National Natural Science Foundation of China

82030105

Shanghai Rising-Star Program

20QA1411700