Ru(II)-Fenamic-Based Complexes as Promising Human Ovarian Antitumor Agents: DNA Interaction, Cellular Uptake, and Three-Dimensional Spheroid Models

Marcos V. Palmeira-Mello & Rodrigo S. Correa et al. · 2025-02-18

4Citations
Cancer resistance to chemotherapeutic agents such as cisplatin presents a significant challenge, leading to treatment failure and poor outcomes. Novel metal-based compounds offer a promising strategy to overcome drug resistance and to enhance efficacy. Four Ru(II) complexes with fenamic acid derivatives were synthesized and characterized: [Ru(L)(bipy)(dppp)]PF
Links
DOIPubMed
Journal
Inorganic Chemistry
TL;DR

Four Ru(II) complexes with fenamic acid derivatives exhibited notable cytotoxicity against tested cell lines, particularly A2780 and A2780cisR (cisplatin-resistant ovarian tumors), compared to MDA-MB-231 (breast) and A549 (lung) lines.

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Institutions
Department Of Chemistry MalaysiaUniversidade Estadual Paulista UnespUniversidade De So PauloInstitut Des Sciences Biologiques
Authors
Marcos V. Palmeira-Mello, José A. Gomes Neto, Javier Ellena, Fillipe Vieira Rocha, Rodrigo S. Correa
Funding
Funda??o de Amparo ? Pesquisa do Estado de Minas Gerais Grant APQ-01963-23Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico Grant 315204/2023-0Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo Grant 2021/01787-0Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo Grant 2022/14041-0Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo Grant 2023/02475-8Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo Grant 2024/02879-4Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Funding