Ultrasensitive Electrochemiluminescence Nanoprobe for Early Screening and Early Diagnosis of Cervical Cancer

Qihui Zhou & Bin Cai · 2026-03-11

High-risk HPV-16 infection is strongly linked to cervical cancer, making its quantitative detection vital for early screening and early diagnosis. However, accurate detection of HPV-16 DNA is challenging due to the low viral load and biomolecular interference in the cervical microenvironment. Here, we develop an electrochemiluminescence sensor using in situ-grown MXene quantum dots immobilized on N, P-codoped Ti
Links
DOIPubMed
Journal
Analytical Chemistry
TL;DR

An electrochemiluminescence sensor using in situ-grown MXene quantum dots immobilized on N, P-codoped Ti3C2 sheets as a nanoprobe for HPV-16 DNA detection and CRISPR/Cas12a recognition indicates that the N, P-Ti3C2-MQDs-Cas12a system is a promising platform for supporting early screening and diagnosis of cervical cancer.

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Institutions
Qingdao Municipal HospitalChemistry And Chemical Engineering Research Center Of Iran
Authors
Qihui Zhou, Bin Cai
Funding
Qingdao Municipal Science and Technology Bureau Grant 24-1-4-xxgg-10-nshQingdao Municipal Science and Technology Bureau Grant 25-1-1-gjgg-66-nshQingdao Municipal Science and Technology Bureau Grant 25-1-1-yqpy-17-qyNational Key Research and Development Program of China Grant 2022YFF0713100National Key Research and Development Program of China Grant 2023YFA0918404National Key Research and Development Program of China Grant 2023YFFO715101Natural Science Foundation of Qingdao Municipality Grant 25-1-1-64-zyyd-jchYantai Science and Technology Bureau Grant 2021RC016Taishan Scholar Foundation of Shandong Province Grant tsqn202306272National Natural Science Foundation of China Grant 8257072650Natural Science Foundation of Shandong Province Grant ZR2024YQ068