Ultrasensitive Electrochemiluminescence Nanoprobe for Early Screening and Early Diagnosis of Cervical Cancer

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doi:10.1021/acs.analchem.5c08162

Ultrasensitive Electrochemiluminescence Nanoprobe for Early Screening and Early Diagnosis of Cervical Cancer

· 2026-03-11

High-risk HPV-16 infection is strongly linked to cervical cancer, making its quantitative detection vital for early screening and early diagnosis. However, accurate detection of HPV-16 DNA is challenging due to the low viral load and biomolecular interference in the cervical microenvironment. Here, we develop an electrochemiluminescence sensor using in situ-grown MXene quantum dots immobilized on N, P-codoped Ti

Links

DOI PubMed

Journal

Analytical Chemistry

TL;DR

An electrochemiluminescence sensor using in situ-grown MXene quantum dots immobilized on N, P-codoped Ti3C2 sheets as a nanoprobe for HPV-16 DNA detection and CRISPR/Cas12a recognition indicates that the N, P-Ti3C2-MQDs-Cas12a system is a promising platform for supporting early screening and diagnosis of cervical cancer.

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Funding

Qingdao Municipal Science and Technology Bureau

24-1-4-xxgg-10-nsh

Qingdao Municipal Science and Technology Bureau

25-1-1-gjgg-66-nsh

Qingdao Municipal Science and Technology Bureau

25-1-1-yqpy-17-qy

National Key Research and Development Program of China

2022YFF0713100

National Key Research and Development Program of China

2023YFA0918404

National Key Research and Development Program of China

2023YFFO715101

Natural Science Foundation of Qingdao Municipality

25-1-1-64-zyyd-jch

Yantai Science and Technology Bureau

2021RC016

Taishan Scholar Foundation of Shandong Province

tsqn202306272

National Natural Science Foundation of China

8257072650

Natural Science Foundation of Shandong Province

ZR2024YQ068