Mechanisms of T cell-mediated immune evasion in cervical cancer: a comprehensive bibliometric analysis and future research directions
Cervical cancer, a prevalent malignancy caused by high-risk HPV strains, remains a significant challenge due to its ability to evade the immune system, particularly T cell-mediated responses. This study aims to explore the research landscape surrounding T cell-mediated immune evasion in cervical cancer through a comprehensive bibliometric analysis. Using data from the Web of Science Core Collection (2014-2023), we employed VOSviewer, CiteSpace, and the R package "bibliometrics" to conduct co-citation and co-occurrence analyses, identifying key trends, contributors, and research hotspots. Our analysis included 930 studies from 68 countries, with China, the USA, and the Netherlands as the leading contributors. Emerging topics include immune checkpoint inhibitors, PD-L1, and tumor microenvironment modulation, highlighting the growing focus on immune-based therapies. This study provides valuable insights into the role of T cells in cervical cancer progression and offers a foundation for future research directions aimed at improving immunotherapy outcomes in cervical cancer patients.