Cancer-testis antigen ACRBP: Cytotoxic response to its HLA-A2 restricted peptide and immune features in ovarian cancer

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doi:10.1080/21645515.2025.2557096

Cancer-testis antigen ACRBP: Cytotoxic response to its HLA-A2 restricted peptide and immune features in ovarian cancer

Xia Zeng & Xiao-Xun Xie et al. · 2025-10-16

While our prior study identified the HLA-A *0201-restricted ACRBP epitope peptide and demonstrated its capacity to generate cytotoxic T lymphocytes (CTLs) in vitro, the clinical relevance of the peptide-induced T cell reactivity in ovarian cancer (OC) patients and the in vivo anti-tumor efficacy of these CTLs remain unexplored. In this study, dendritic cells were sensitized with ACRBP peptide (ALLVLCYSI) and co-cultured with autologous CD8

Links

DOI PubMed

Journal

Human Vaccines & Immunotherapeutics

Authors

Xia Zeng, Li-Na Lin, Xiaoquan Li, Wei-Xia Nong, Feng Li, Li Lan, Ping Wang, Ai Ye, Qing-Mei Zhang, Bin Luo, Ying-Ying Ge, Xiao-Xun Xie

Funding

Guangxi Natural Science Foundation Grant 2024GXNSFAA010009 Natural Science Foundation of Guangxi Province Grant 2025GXNSFBA069061 First-Class Discipline Construction Project in Basic Medicine of Guangxi Mudical University Grant DC2300011025 Special Fund for Talent Development of Guangxi Zhuang Autonomous Region Grant DC2400002995