Starvation-inactivated MTOR triggers cell migration via a ULK1-SH3PXD2A/TKS5-MMP14 pathway in ovarian carcinoma

Chiao-Yun Lin & Chia-Lung Tsai et al. · 2023-07-28

16Citations
AMPK: AMP-activated protein kinase; CHX: cycloheximide; RAD001: everolimus; HBSS: Hanks' balanced salt solution; LC-MS/MS: liquid chromatography-mass spectrometry/mass spectrometry; MMP14: matrix metallopeptidase 14; MTOR: mechanistic target of rapamycin kinase; MAPK: mitogen-activated protein kinase; RB1CC1/FIP200: RB1 inducible coiled-coil 1; PtdIns3P: phosphatidylinositol-3-phosphate; PX: phox homology; SH3: Src homology 3; SH3PXD2A/TKS5: SH3 and PX domains 2A; SH3PXD2A-[6A]: S112A S142A S146A S147A S175A S348A mutant; ULK1: unc-51 like autophagy activating kinase 1.
Links
DOIPubMed
Journal
Autophagy
TL;DR

The results suggest that the ULK1-SH3PXD2A-MMP14 axis might regulate the biological aggressiveness of ovarian cancer and serve as a therapeutic target in this malignancy.

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Authors
Chiao-Yun Lin, Kai-Yun Wu, Lang-Ming Chi, Yun-Hsin Tang, Huei-Jean Huang, Chyong-Huey Lai, Chi-Neu Tsai, Chia-Lung Tsai
Funding
the National Science and Technology Council, Taiwan Grant 111-2314-B-182A-035-MY3Chang Gung Medical Research Foundation, Taiwan Grant CMRPG3L1431Chang Gung Medical Research Foundation, Taiwan Grant CMRPG3M0801Chang Gung Medical Research Foundation, Taiwan Grant and CMRPG3M1291 to CLTChang Gung Medical Research Foundation, Taiwan Grant CMRPG3M0761