Functional validation of somatic variability in
            TP53
            and
            KRAS
            for prediction of platinum sensitivity and prognosis in epithelial ovarian carcinoma patients

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Pavel Souček

doi:10.1080/15384047.2025.2543105

Functional validation of somatic variability in TP53 and KRAS for prediction of platinum sensitivity and prognosis in epithelial ovarian carcinoma patients

Pavel Souček · 2025-08-10

Concerning the dismal prognosis of chemoresistant patients with epithelial ovarian carcinoma (EOC), we aimed to follow up the findings of a previous whole-exome sequencing study using an orthogonal Sanger sequencing on the same patients and a separate set of 127 EOC patients (

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Cancer Biology & Therapy

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The study points to KRAS as a target for future therapy of nonHGSCs and reveals the prognostic value of TP53 variants in the DNA binding loop.

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Functional validation of somatic variability in TP53 and KRAS for prediction of platinum sensitivity and prognosis in epithelial ovarian carcinoma patients

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