Functional validation of somatic variability in
            TP53
            and
            KRAS
            for prediction of platinum sensitivity and prognosis in epithelial ovarian carcinoma patients

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Pavel Souček

doi:10.1080/15384047.2025.2543105

Functional validation of somatic variability in TP53 and KRAS for prediction of platinum sensitivity and prognosis in epithelial ovarian carcinoma patients

Pavel Souček · 2025-08-10

Concerning the dismal prognosis of chemoresistant patients with epithelial ovarian carcinoma (EOC), we aimed to follow up the findings of a previous whole-exome sequencing study using an orthogonal Sanger sequencing on the same patients and a separate set of 127 EOC patients (

Funding

the Ministry of Health of the Czech Republic in cooperation with the Czech Health Research Council

NU22-08-00186

Grant Agency of Charles University

307123

Agentura Pro Zdravotnický Výzkum České Republiky

NU22-08-00186

Functional validation of somatic variability in TP53 and KRAS for prediction of platinum sensitivity and prognosis in epithelial ovarian carcinoma patients

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