Clinical risk factors and predictive value of inflammatory biomarkers for 2-year recurrence after standard surgery for endometrial cancer: a retrospective study among the Chinese population
This study aimed to identify risk factors for recurrence after surgery for endometrial carcinoma in Chinese patients and to develop a postoperative surveillance model integrating preoperative biomarkers with postoperative pathological features. We retrospectively reviewed the clinical records of pathologically diagnosed endometrial cancer patients who underwent surgical treatment between January 2019 and December 2022. Patients were stratified into recurrence (n = 80) and non-recurrence (n = 282) cohorts based on 2-year follow-up results (median follow-up: 46 months). Data collected included demographics, postoperative pathological features, treatment details, and preoperative laboratory indices. Multivariable logistic regression identified advanced postoperative International FIGO stage, larger postoperative tumor size, higher preoperative pan-immune-inflammation value (PIV), and elevated preoperative C-reactive protein (CRP) as independent risk factors for recurrence, while higher preoperative albumin (Alb) was a protective factor (all Advanced FIGO stage, larger tumor size, elevated PIV and CRP, and reduced albumin are key predictors of recurrence. Combining these factors provides a strong model for individualized postoperative surveillance.