Antibody therapeutics for epithelial ovarian cancer
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High-grade serous ovarian carcinoma (HGSC) is an aggressive subtype of epithelial ovarian carcinoma (EOC) and remains the most lethal gynecologic cancer. A lack of effective and tolerable therapeutic options and nonspecific symptoms at presentation with advanced stage of disease are among the challenges in the management of the disease. An overview of ovarian cancer, followed by a discussion of the current therapeutic regimes and challenges that arise during and after the treatment of EOC. We discuss different formats of antibody therapeutics and their usage in targeting validated targets implicated in ovarian cancer, as well as three emerging novel proteins as examples recently implicated in their contribution to adaptive resistance in ovarian cancer. Antibody therapeutics allow for a unique and effective way to target proteins implicated in cancer and other diseases, and have the potential to radically change the outcomes of patients suffering from ovarian cancer. The vast array of targets that have been implicated in ovarian cancer and yet the lack of effective therapeutic options for patients further stresses the importance of discovering novel proteins that can be targeted, as well as predictive biomarkers that can inform the stratification of patients into treatment-specific populations.
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Cancer Center Support GrantCore 1: Pathology CoreHarnessing the power of exosomes for non-coding RNA deliveryCancer Prevention and Research Institute of Texas Grant RP150551Cancer Prevention and Research Institute of Texas Grant RP190561Welch Foundation Grant AU-0042-20030616Core 1: Pathology CoreHarnessing the power of exosomes for non-coding RNA deliveryCancer Center Support GrantOvarian Cancer Research Alliance FundingAmerican Cancer Society FundingFrank McGraw Memorial Chair in Cancer Research Funding